Which of the following medications is typically used to treat both fatigue and depression in MS patients?

Modafinil is known for its role in managing fatigue, particularly in patients with multiple sclerosis (MS). It is a wakefulness-promoting agent that helps improve alertness and reduce excessive daytime sleepiness, which can be common in individuals with MS. This medication is often considered when fatigue significantly impacts daily functioning.

Additionally, there is evidence that Modafinil can also have a positive effect on mood, which may assist in alleviating depressive symptoms. Depression is another prevalent issue for many with MS, and Modafinil's dual action of enhancing wakefulness and potentially improving mood makes it a suitable choice in this context.

In contrast, other options have more specialized uses and do not typically address both fatigue and depression effectively. For example, botulinum toxin is primarily used for muscle spasticity and does not target fatigue or depression. Amantadine, while it can be used to combat fatigue, does not have robust applications for treating depressive symptoms directly. Tizanidine is primarily a muscle relaxant used to relieve spasticity and does not provide benefits for fatigue or mood disorders. Thus, Modafinil stands out as the preferred treatment in this instance due to its dual impact on fatigue and depressive symptoms in MS patients.