How is intrathecal baclofen typically administered for spasticity?

Intrathecal baclofen is a medication used to manage spasticity, particularly in conditions such as multiple sclerosis, cerebral palsy, and spinal cord injury. The administration route involves delivering the medication directly into the cerebrospinal fluid (CSF) within the spinal canal. This method allows for targeted treatment with lower doses of the drug, which can minimize systemic side effects and provide enhanced efficacy in reducing muscle spasticity.

Using an implanted pump for delivery enables continuous infusion of baclofen, ensuring consistent therapeutic levels and providing the flexibility to adjust the dose as required for optimal management of symptoms. This method involves surgical implantation of a reservoir and catheter system, which can be programmed to deliver the medication over time.

Other methods of administration, such as orally, through muscle injection, or topically, are generally not utilized for baclofen due to factors such as inadequate efficacy, potential systemic side effects, and the need for direct medication influence on the spinal cord and surrounding tissues. Thus, the implanted pump is the established and effective method for intrathecal delivery of baclofen for spasticity management.